Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Huwentoxin-IV TFA | 105856-78-4 | 99.04% | 4099.71 | 5 MG
Huwentoxin-IV TFA is a highly potent and selective blocker of neuronal voltage-gated sodium channels. It specifically inhibits NaV1.7 activity in human DRG neurons.
- Potent and selective sodium channel blocker
- Inhibits neuronal NaV1.7, NaV1.2, NaV1.3, and NaV1.4 channels
- IC50 of 2.9 nM for inhibiting NaV1.7-mediated currents
- Reduces NaV1.7 current amplitude by 50% at 0.5 nM
Medchemexpress LLC TL033 | 2356230-22-1 | 1630.83 | 25 MG
TL033 is a chemical substance identified for laboratory use, including the manufacture of other substances. It is supplied as a solid and is intended for research purposes only by experienced personnel.
- Identified for laboratory chemical manufacturing
- Supplied as a solid
- Recommended storage at -20°C, protected from light
- Stable under recommended storage conditions
- For research use only
Covachem Trifluoroacetic Acid | 76-05-1 | MFCD00004169 | 10 x 1 mL
This item has a minimum order quantity of 2 per supplier requirements.
Trifluoroacetic Acid | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 10 x 1 mL
Medchemexpress LLC CPN-351 TFA | 912.11 (free base) | 5 MG
CPN-351 TFA, a pentapeptide, acts as a selective antagonist for human NMUR1, demonstrating a pA2 of 7.35. Its antagonistic effect on human NMUR1 is significantly higher, specifically 10 times greater, than its effect on NMUR2. This compound is suitable for application in inflammation research.
- Selective antagonist of human NMUR1.
- Pentapeptide compound.
- Antagonistic effect on human NMUR1 is 10 times higher than on NMUR2.
- Used in the study of inflammation.
Medchemexpress LLC ATX-II (TFA) | 99.65% | 4934.62 (free acid) | 100 UG
ATX-II TFA is a selective sodium channel modulator toxin that enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. This compound exhibits a pro-arrhythmic effect by slowing intrinsic heart rate, prolonging the QT interval and sinus node recovery time, and inducing sinus pauses and arrests. It is suitable for research related to atrial fibrillation, long QT syndrome, and long QT3 syndrome.
- Enhances tetrodotoxin sensitive resurgent and persistent sodium currents in large diameter mouse DRG neurons.
- Shifts the voltage dependence of activation and steady-state fast inactivation of TTXS sodium channels to more hyperpolarized potentials.
- Increases diastolic tension and arrhythmia score in isolated rat right atrial tissue.
- Significantly increases diastolic intracellular Ca2+ concentrations in isolated rat atrial myocytes.
Waters Corp Proteomics Training Standards, Kit
Waters Corporation Proteomics Training Standards, Kit
Medchemexpress LLC Pardaxin P5 TFA | ≥96% | 3381.87 (free base) | 5 MG
Pardaxin P5 TFA is the TFA salt form of Pardaxin P5, an antimicrobial peptide that inhibits Escherichia coli with a MIC value of 13 μM. This peptide is for research use only.
- Inhibits Escherichia coli
- Antimicrobial peptide
- Available in solid form
- Molecular weight of 3381.87 (free base)
- Store at -80°C for 2 years (powder) or 6 months (in solvent)