Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Bibo3304 trifluoroacetate | 191868-14-1 | MFCD04112989 | 100.0% | 643.66 g·mol⁻¹ | C31H36F3N7O5 | 10 MG
BIBO3304 is a potent, selective neuropeptide Y (NPY) Y1 receptor antagonist used in pharmacological and receptor biology research. Supplied as a trifluoroacetate salt in solid form, it is characterized by a defined molecular formula and molecular weight and is intended for in vitro and in vivo experimental applications.
- Potent NPY Y1 receptor antagonist with subnanomolar affinity.
- High reported purity suitable for research-grade assays.
- Stable solid trifluoroacetate salt for convenient handling and storage.
- Available in small milligram quantities and pre-made DMSO solutions for assay readiness.
- Characterized molecular weight and formula to support analytical and dosing calculations.
Medchemexpress LLC L-lysine, L-lysyl-L-glutaminyl-L-phenylalanyl- | 99.6% | 891.73 | 5 MG
KQFK TFA is an inactive control peptide, supplied as the TFA salt form. This compound, with a molecular formula of C32H46F9N7O12 and a molecular weight of 891.73, presents as a white to off-white solid with a purity of 99.6%. It is intended for research use only.
- Inactive control peptide, TFA salt form
- White to off-white solid appearance
- High purity of 99.6%
- Powder can be stored for 2 years at -80°C or 1 year at -20°C in sealed conditions, away from moisture
- In solvent, stable for 6 months at -80°C or 1 month at -20°C with sealed storage, away from moisture
Medchemexpress LLC UNC4976 trifluoroacetate | 98.0% | 961.12 g/mol | C49H71F3N6O10 | 5 MG
UNC4976 TFA is the trifluoroacetate salt of UNC4976, a peptidomimetic positive allosteric modulator (PAM) of the CBX7 chromodomain that modulates chromodomain-nucleic acid interactions. It is supplied as a purified research compound intended for in vitro studies in epigenetics and chromatin biology.
- Trifluoroacetate salt form for improved handling and stability.
- High purity suitable for research applications (98.0%).
- Molecular formula C49H71F3N6O10 and molecular weight 961.12 g/mol.
- Available in small pack sizes for screening and assay development.
- Suitable for use in studies of chromodomain function and epigenetic modulation.
- Provided with documentation specifying identity and purity.
![Medchemexpress LLC 6-Benzothiazolamine, N-[6-[2-[(cyclohexylmethyl)amino]-4-(trifluoromethyl)phenyl]-4-pyrimidinyl]- (TFA) | 99.1% | 597.58 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438226-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 6-Benzothiazolamine, N-[6-[2-[(cyclohexylmethyl)amino]-4-(trifluoromethyl)phenyl]-4-pyrimidinyl]- (TFA) | 99.1% | 597.58 | 25 MG
AMG 7905 TFA is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. It potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin.
- Potentiates TRPV1 channels activation by protons
- Drives reflectory inhibition of thermogenesis and tail-skin vasoconstriction
- Potently blocks channel activation by capsaicin
Medchemexpress LLC MC-VC-PAB-NH2 trifluoroacetic acid | 1616727-21-9 | 99.9% | C33H47F3N8O10 | 10MG
MC-VC-PAB-NH2 TFA is a cleavable ADC linker supplied as the trifluoroacetic acid salt for research use. It contains a Val-Cit-PAB cleavable spacer designed for protease-triggered drug release and is provided as a white to off-white solid with high purity.
- Provides a protease-cleavable Val-Cit-PAB spacer for controlled payload release.
- Supplied as a TFA salt to aid handling and stability.
- High purity (≈99.9%) suitable for conjugation workflows.
- Soluble in DMSO at high concentration (100 mg/mL) with ultrasonic assistance.
- Solid, white to off-white appearance for convenient storage and handling.
- Storage recommendations: sealed, away from moisture and light; in solvent: -80°C (6 months), -20°C (1 month).
- Intended for research use only; not for human or clinical use.
![Medchemexpress LLC L-prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl] TFA | 157379-44-7 | 99.3% | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232164.png-250.jpg)
Medchemexpress LLC L-prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl] TFA | 157379-44-7 | 99.3% | 25 MG
PPACK (TFA) is the trifluoroacetate salt of a peptide-based irreversible thrombin inhibitor supplied as a white to off-white solid. It is used in biochemical assays to inhibit thrombin activity and for anticoagulation research.
- Irreversible thrombin inhibitor for biochemical assays.
- High purity of 99.3% as determined by HPLC.
- White to off-white solid form suitable for storage and handling.
- Recommended storage conditions for powder and solvent are provided in the COA.
- Molecular weight 564.99 and formula C23H32ClF3N6O5.
Medchemexpress LLC SRI 31215 TFA 10mM 1mL | 1832686-44-8 | 1 ML
SRI 31215 (trifluoroacetate) is the TFA salt of a small-molecule inhibitor targeting matriptase, hepsin, and hepatocyte growth factor activator (HGFA). Supplied as a 10 mM solution in DMSO (1 mL), it is intended for in vitro research applications.
- Trifluoroacetate salt.
- Matriptase, hepsin, and HGFA inhibitor.
- Supplied as a 10 mM solution in DMSO, 1 mL.
- High reported purity of 98.5%.
- Molecular formula C27H34F3N5O3; molecular weight 533.59 g/mol.
Medchemexpress LLC UNC0379 trifluoroacetate | 1620401-83-3 | MFCD28167817 | 99.9% | 527.58 g·mol⁻¹ | C25H36F3N5O4 | 5MG
UNC0379 trifluoroacetate is the trifluoroacetate salt of UNC0379, a selective substrate-competitive inhibitor of the lysine methyltransferase SETD8 (KMT5A). It is supplied as a high-purity research reagent for biochemical and cellular studies, with reported activity IC50 = 7.3 μM and KD = 18.3 μM. For laboratory research use only.
Medchemexpress LLC Survodutide TFA | 99.4% | 4231.62 (free base) | 25 MG
Survodutide TFA is a potent and selective dual agonist targeting the glucagon receptor (GCGR) and GLP-1 receptor (GLP-1R), with EC50s of 0.52 nM and 0.33 nM respectively in CHO-K1 cells. This 29-amino-acid acylated peptide, featuring a C18 fatty acid, demonstrates significant anti-obesity efficacy by enhancing energy expenditure and reducing food intake.
- Potent, selective GCGR/GLP-1R dual agonist
- EC50s of 0.52 nM (GCGR) and 0.33 nM (GLP-1R)
- 29-amino-acid acylated peptide
- Contains a C18 fatty acid
- Demonstrates robust anti-obesity efficacy
- Increases energy expenditure and decreases food intake
- Enhanced proteolytic stability
- Extended terminal half-life
Medchemexpress LLC Dendrotoxin K TFA | 119128-61-9 | 6559.66 | 500 UG
Dendrotoxin K functions as a Kv1.1 channel blocker. It plays a role in determining glutamate release within CA3 neurons by controlling the presynaptic spike waveform in a time-dependent manner.
- Acts as a Kv1.1 channel blocker.
- Influences glutamate release in CA3 neurons.
- Regulates the presynaptic spike waveform in a time-dependent manner.
- Intended for research use only.
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 50 MG
Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 50 MG
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid Reage
TRIFLUOROACETIC Trifluoroacetic acid Reage
Medchemexpress LLC Semaglutide (TFA) | 99.9% | 4113.58 | 1 MG
Semaglutide (TFA) | 99.9% | 4113.58 | 1 MG
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC), 76-05-1, MFCD00004169
Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC)
eMolecules 76-05-1 | Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100g | 537709016
Trifluoroacetic acid, >=99.995% Trace metals grade | Oakwood Chemical | 76-05-1 | MFCD00004169 | 114.023 | C2HF3O2 | 99.000 | OC(=O)C(F)(F)F | 100g | 537709016