Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Qtx125 TFA | 2989537-78-0 | 99.9% | 50MG
Qtx125 TFA | 2989537-78-0 | 99.9% | 50MG
Medchemexpress LLC Lys-bradykinin TFA | 99.9% | 1188.38 g/mol | C56H85N17O12 · x C2HF3O2 | 50 MG
Lys-Bradykinin TFA is the trifluoroacetate salt of Lys-Bradykinin (kallidin), a biologically active nonapeptide ligand for bradykinin/kallidin receptors. Supplied as a solid peptide powder for research use, it is commonly used in studies of vascular regulation, inflammation, and receptor pharmacology.
- Trifluoroacetate salt of Lys-Bradykinin (kallidin).
- Purity 99.85%.
- Molecular weight 1188.38 g/mol.
- Available as solid powder, including 50 MG size.
- Storage: powder -80°C for 2 years, -20°C for 1 year; in solvent -80°C for 6 months, -20°C for 1 month.
- Documentation includes COA, RP-HPLC, LCMS, elemental analysis, and SDS.
Medchemexpress LLC BIM 23042 (trifluoroacetate) | 00-00-0 | MFCD32666112 | 96.2% | 1192.45 g/mol | C63H73N11O9S2·xC2HF3O2 | 1 MG
BIM 23042 (trifluoroacetate) is a somatostatin-like octapeptide analogue that acts as a selective neuromedin B receptor (NMB-R/BB1) antagonist. It is supplied as the trifluoroacetate salt in solid form for research use in receptor pharmacology and intracellular calcium signaling studies.
- Selective neuromedin B receptor (NMB-R/BB1) antagonist.
- Somatostatin-like octapeptide structure as the trifluoroacetate salt.
- Purity approximately 96.2% by supplier analysis.
- White to off-white solid powder suitable for laboratory use.
- Store sealed away from moisture and light; powder stable at -80°C (2 years) or -20°C (1 year).
Medchemexpress LLC 4,7,10,13,16-pentaazanonadecanedioic acid ester (TFA) | MFCD34677028 | 98.6% | 1841.72 (free base) | C93H173N5O20S5·xC2HF3O2 | 5 MG
5A2-SC8 TFA is an ionizable amino lipid provided as the trifluoroacetic acid salt for formulation into lipid nanoparticles (LNPs). It is intended for research use to enable efficient delivery of small RNAs, such as siRNA and miRNA, and has documented low in vivo toxicity and COA-verified purity.
- Ionizable amino lipid suitable for LNP formulation.
- Enhances delivery of siRNA and miRNA to target cells.
- Low in vivo toxicity profile reported.
- Provided as the TFA salt to aid formulation and handling.
- COA-verified purity by HPLC (~98.6%).
- Store at -80 °C and protect from light for stability.
Medchemexpress LLC Pemvidutide trifluoroacetate | 98.1% | 3873.35 | C182H275N39O54 | 5 MG
Pemvidutide TFA is a synthetic peptide acting as a dual agonist of the GLP-1 and glucagon receptors. Supplied for research use, it has been investigated for reductions in body weight, liver fat, and serum lipids, and is intended for preclinical and in-vitro studies only.
- Dual GLP-1 and glucagon receptor agonist activity.
- High purity (98.1%).
- Molecular weight 3873.35 Da.
- Provided as the trifluoroacetate salt for peptide stability.
- Available in small milligram sizes for research workflows.
- Store powder at -80°C (up to 2 years) or -20°C (up to 1 year).
Medchemexpress LLC Ncgc00138783 TFA | 00-00-0 | 99.4% | 617.62 g·mol⁻¹ | C28H27F4N7O3S | 5 MG
NCGC00138783 TFA is a small-molecule inhibitor that selectively targets the CD47/SIRPα immune checkpoint, blocking the CD47-SIRPα interaction with reported in vitro activity (IC50 ≈ 50 μM). Supplied as the trifluoroacetic acid (TFA) salt for research applications.
- Selective inhibitor of the CD47/SIRPα immune checkpoint.
- Reported IC50 approximately 50 μM in biochemical assays.
- Supplied as the trifluoroacetic acid (TFA) salt.
- High purity (99.4%).
- Molecular weight 617.62 g·mol⁻¹.
- Store at 4 °C; protect from moisture and light.
Medchemexpress LLC L-lysyl-L-cysteine trifluoroacetate | 97.8% | 477.38 g/mol | C13H21F6N3O7S | 5 MG
L-lysyl-L-cysteine trifluoroacetate is a dipeptide formed from lysine and cysteine, provided as a solid TFA salt for research use. The material is characterized by a reported purity, defined molecular formula and molecular weight, and specified storage recommendations for powder and solutions.
- Dipeptide composed of lysine and cysteine.
- Supplied as trifluoroacetate (TFA) salt in solid powder form.
- Reported purity 97.8%.
- Molecular formula C13H21F6N3O7S and molecular weight 477.38 g/mol.
- Available in small research quantities: 5 mg, 10 mg, 25 mg.
- Store sealed, away from moisture; powder: -80°C for 2 years, -20°C for 1 year; in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC MIP-1095 trifluoroacetate | 00-00-0 | MFCD09802015 | 99.8% | 678.35 g/mol | C21H26F3IN4O10 | 5 MG
MIP-1095 trifluoroacetate is a small-molecule inhibitor of prostate-specific membrane antigen used for research and imaging probe development. The compound is supplied as a high-purity trifluoroacetate salt, suitable for radiolabeling and preclinical assays.
- Potent inhibitor of prostate-specific membrane antigen (PSMA).
- Provided as trifluoroacetate (TFA) salt for stability.
- High purity suitable for research applications.
- Compatible with radiolabeling for imaging probe development.
- Soluble in DMSO for assay preparation.
- Available in small-mass quantities for preclinical studies.
Medchemexpress LLC MTvkPABC-P5 TFA | 98.8% | 1190.22 Da | C54H74F3N11O16 | 1 MG
MTvkPABC-P5 TFA is the trifluoroacetic acid (TFA) salt form of a Toll-like receptor 7 (TLR7) agonist used as an immune stimulant and as a synthetic building block for immune-stimulating antibody conjugates (ISACs).
- Acts as a Toll-like receptor 7 (TLR7) agonist and immune stimulant.
- Used as a building block for synthesis of immune-stimulating antibody conjugates (ISACs).
- Provided as a TFA salt for improved handling and stability.
- Reported high purity suitable for research use.
- Offered in small mg pack sizes for laboratory applications.
Medchemexpress LLC Galnon TFA | 1217448-19-5 | MFCD06798339 | 98.9% | 792.84 | C42H47F3N4O8 | 5 MG
Galnon TFA is a selective, non-peptide agonist of galanin receptors GAL1 and GAL2 used in neuroscience research. It binds GAL1 and GAL2 with reported Kis of 11.7 μM and 34.1 μM and has demonstrated anticonvulsant and anxiolytic effects. The compound is supplied as a white to off-white solid with high purity and is soluble in DMSO for in vitro use.
- Selective galanin receptor agonist (GAL1 and GAL2).
- Demonstrated anticonvulsant and anxiolytic activity in preclinical models.
- High purity (98.9%) and white to off-white solid appearance.
- Soluble in DMSO (125 mg/mL); use fresh DMSO and ultrasonic assistance if needed.
- Recommended storage sealed, protected from moisture and light; frozen solution stability varies by temperature.
Medchemexpress LLC NLS-StAx-h TFA | 98.9% | 3559.28 | 1 MG
NLS-StAx-h TFA is a selective, cell permeable, stapled peptide that inhibits Wnt signaling, with an IC50 of 1.4 μM. It effectively inhibits interactions between β-catenin and transcription factors and demonstrates anti-proliferative effects on cancer cells, including SW-480 and DLD-1 colorectal cancer cells.
- Selective, cell permeable, stapled peptide
- Inhibits Wnt signaling with an IC50 of 1.4 μM
- Efficiently inhibits β-catenin-transcription factor interactions
- Shows anti-proliferation of cancer cells
- Inhibits proliferation of colorectal cancer cells (SW-480 and DLD-1 cells) by more than 80% at 10 μM
- Inhibits migration of DLD-1 colorectal cancer cells in a dose-dependent manner
Medchemexpress LLC OS-2966 5mg | 5mg
OS-2966 is a humanized antibody expressed in CHO cells targeting Integrin b1/ITGB1/CD29 OS-2966 carries a huIgG1 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 5 kDa The isotype control for OS-2966 can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC OS-2966 10mg | 10mg
OS-2966 is a humanized antibody expressed in CHO cells targeting Integrin b1/ITGB1/CD29 OS-2966 carries a huIgG1 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 5 kDa The isotype control for OS-2966 can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC N-acetyl-L-valyl-L-alpha-glutamyl-L-isoleucyl-L-aspart-1-al | 00-00-0 | MFCD01318861 | 99.8% | 614.57 g/mol | C24H37F3N4O11 | 5 MG
Ac-VEID-CHO TFA is a peptide-derived aldehyde inhibitor of caspases used in biochemical research to study apoptosis and neurodegenerative disease mechanisms. The trifluoroacetate salt is supplied as a white to off-white solid with high purity and is suitable for assays requiring nanomolar potency against executioner caspases.
- Purity 99.8% by HPLC.
- Potent inhibition of caspase-3, caspase-6, and caspase-7 (IC50: 13.6 nM, 16.2 nM, 162.1 nM).
- Supplied as a solid, white to off-white powder.
- Soluble in water at approximately 1 mg/mL with sonication and warming.
- Storage recommendations include cold, sealed conditions to preserve stability.
- Designed for research applications in apoptosis and neurodegenerative disease models.
- Available in small research-scale quantities for assay development.
Medchemexpress LLC Lys-CoA TFA (Lys-coenzyme A) | 98.5% | 1 MG
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of 50-500 nM. It demonstrates over 100-fold selectivity for p300 compared to PCAF (IC50=200 μM). This compound works by inhibiting p300 HAT activity-dependent transcriptional activation.
- Selective p300 histone acetyltransferase (HAT) inhibitor
- IC50 of 50-500 nM for p300
- Over 100-fold selectivity for p300 compared to PCAF
- Induces a senescent phenotype in human normal melanocytes at 0.1 and 1 mM concentrations
- Inhibits cyclin E expression in a dose-dependent manner